An innovative and fast peer-review process is used to … Create search list. For instance, deletion 11q has been associated with either better or worse outcome during ibrutinib treatment in different trials, and some traditional prognostic markers defined in the era of CIT, such as IGHV mutational status, were not included in the four-factor model. Access the latest research on COVID-19, including preprints, on Scilit. The study of AML subtypes allows us to define the mutations that can impact disease outcome and to define the clonal evolution at the molecular level. HemaSphere is an open access journal dedicated to support hematology patient care, research and education worldwide. Its interface has been designed to access the bibliometric indicators database of the SCImago Journal & Country Rank portal. ... A factor limiting the efficacy of CSL362 in vivo is the limited number of NK lymphocytes present in some cancer patients. THIS MANUSCRIPT IS PUBLISHED AS AN OFFICIAL SUPPLEMENT OF HEMASPHERE. Tamara J. Blätte, Marcin M. Machnicki, Eliza Glodkowska-Mrowka, Anna Dolnik, Marta Karp, Agnieszka Karczmarczyk, HemaSphere, Volume 5; doi:10.1097/hs9.0000000000000514, HemaSphere, Volume 5; doi:10.1097/hs9.0000000000000487. We also discuss progress being made in preclinical studies for challenging disease targets and emerging gene editing technologies that are showing promising results, particularly for conditions where gene regulation is important for efficacy. PAIN Reports. Using multivariable models, we confirmed that these associations were independent of the potential confounding factors obesity, smoking, alcohol use, number of medications (as a measure of comorbidity), anemia, and mean corpuscular volume. Search publications Advanced search. Submit an article. Read, Poor Survival and Differential Impact of Genetic Features of Black Patients with Acute Myeloid Leukemia, Bhavana Bhatnagar, et al. Myeloproliferative neoplasms (MPNs) are hematopoietic stem cell disorders with dysregulated myeloid blood cell production and propensity for transformation to acute myeloid leukemia, thrombosis, and bleeding. Debacker et al. THIS MANUSCRIPT IS PUBLISHED AS AN OFFICIAL SUPPLEMENT OF HEMASPHERE. Asian Journal of Transfusion Science (AJTS)Print ISSN: 0973-6247, E-ISSN: 1998-3565) is publication of Indian Society of Blood Transfusion and Immunohemtology (ISBTI), Indian Society of Transfusion Medicine (ISTM). HemaSphere publishes results of highly relevant basic, translational, and clinical research in hematology. This calls for concomitant improvement of our insight into MPN biology to inform tailored therapeutic strategies for individual MPN patients. Finally, the new model includes prior transfusions as an independent adverse factor in line with the findings of Malcovati et al. 1.650 Search in: Advanced search. HemaSphere is the premier hematology information resource, which is covered by the HemaTopics section in the journal. 1-4 However, to the best of our knowledge, it is currently not clear whether smoking also is an unfavorable prognostic factor. No abstract available. 0. Jinjun Cheng, Mohamed Amin Hashem, Frederic Barabé, Stéphanie Cloutier, Liqiang Xi, Mark Raffeld, Stefania Pittaluga, HemaSphere, Volume 5; doi:10.1097/hs9.0000000000000505, For questions or feedback, please reach us at. doi: 10.1097/HS9.0000000000000149. Enter journal title, issn or abbr in this box to search. Blood is a weekly medical journal published by the American Society of Hematology. Review articles and guideline articles will provide clear overviews of new developments and recommendations for patient care. Treatment involves intravenous administration of the deficient factor; it can be done on demand or prophylaxis .Today, the “gold standard” in the treatment of hemophilia is prophylaxis, because it has meant a reduction in joint limitations and an improvement in the quality of life of patients 1,2. As in many other types of cancer, tobacco smoking is suspected to be a risk factor for the development of chronic myeloid leukemia (CML). Complete blood cell counts, including differentials, are widely available and change on aging. List type. The Journal Impact Quartile of mSphere is Q1 . 7A‐D), it added to … With a good balance between the different fields in hematology represented in the journal, we are optimistic that HemaSphere will be awarded with a respectable initial impact factor in 2020. We are especially looking for strong studies reporting novel findings that are of high impact to the field of hematology. Functional modeling of NR3C1 aberrations in pre-B ALL and T-cell ALL cell lines demonstrate that aberrations decreasing NR3C1 expression are important contributors to steroid resistance at disease diagnosis. Impact Analysis. Citation search. In addition, the advances in recent years such as the development of longer‐acting clotting Read our 'format-free' submission policy. HemaSphere - Current Issue. ... HemaSphere … As the journal of the European Hematology Association, HemaSphere is also the premier hematology information resource, which is covered by the HemaTopics section in the journal. Special focus should be placed on myelofibrosis patients with anemia and thrombocytopenia, a delicate patient population at high need for options. The boy weighs 65 kg and receives a weight-dependent dose of 2,720 IU of the coagulation factor three times a week. Combinations of JAK2 inhibition with pegylated interferon-α, a well-established therapy of MPN, B-cell lymphoma 2 inhibition, and others are in clinical development with the potential to enhance therapeutic efficacy. HRQoL was measured using the RAND 36-Item Health Survey. HemaSphere publishes results of highly relevant basic, translational and clinical research in hematology. Marceau-Renaut A, Duployez N, Ducourneau B, Labopin M, Petit A, Rousseau A, & al, Synthèse grand public : Impact pronostique du profil moléculaire des leucémies aiguës myéloïdes pédiatriques : étude du protocole français ELAM02 In July 2017 he was appointed as Editor-in-Chief for the new EHA journal HemaSphere. Autophagy Impact Factor, IF, number of article, detailed information and journal factor. While patients benefit with reduced splenomegaly and symptoms, disease-modifying effects on MPN clone size and clonal evolution are modest. Accordingly, JAK2 inhibitors have held promise for therapeutic targeting. S. Nijhof, Sonja Zweegman, Martine E. D. Chamuleau, Esther C. W. Breij, HemaSphere, Volume 5; doi:10.1097/hs9.0000000000000504. Johanna Ungerstedt - Chair introduction This session provides an update on the latest research and understanding of the impact of spliceosome mutations in Myelodysplastic syndromes (MDS), the role of innate immunity in the pathogenesis of MDS, and finally an update on how to clinically manage high-risk MDS … For instance, deletion 11q has been associated with either better or worse outcome during ibrutinib treatment in different trials, and some traditional prognostic markers defined in the era of CIT, such as IGHV mutational status, were not included in the four-factor model. Does HemaSphere have clear editorial and ethical policies? These aberrations are frequently present in early thymic progenitor-ALL patients and relate to steroid resistance. HemaSphere, Volume 5; doi:10.1097/hs9.0000000000000509. Register now to let HemaSphere know you want to review for them. The Journal Impact 2019-2020 of mSphere is 4.280, which is just updated in 2020. No abstract available. Log in. Blood Research | Read 556 articles with impact on ResearchGate, the professional network for scientists. Create search list HemaSphere, Volume 5; doi:10.1097/hs9.0000000000000526, HemaSphere, Volume 5; doi:10.1097/hs9.0000000000000520, HemaSphere, Volume 5; doi:10.1097/hs9.0000000000000516. We investigated the association between abnormalities in (differential) blood cell counts and HRQoL in 143 191 community-dwelling individuals from the prospective population-based Lifelines cohort. HemaSphere, a premier hematology information resource, publishes results of highly relevant basic, translational and clinical research in hematology. Testosterone‐Induced Repression of Hepcidin Has a Functional Impact on Cell Surface Ferroportin Expression. Publons users have indicated that they sit on HemaSphere's editorial board but we are unable to verify these claims. Top; Official journal of the International Society of Hematology. RNA molecules are a source of phenotypic diversity and an operating system that connects multiple genetic and metabolic processes in the cell. April 2020; HemaSphere 4(2):e343; DOI: 10.1097/HS9.0000000000000343 Check all that apply. Blood. As shown in Fig. MENU. Following engagement by natural ligand 4-1BBL, 4-1BB transduces the activation signal of NF-κB, ... HemaSphere (2018) 2(5):e149. April 2020; HemaSphere 4(2):e343; DOI: 10.1097/HS9.0000000000000343 Peripheral blood cell counts outside the normal range have previously been associated with increased mortality rates and a number of comorbid conditions. HemaSphere anticipates receiving an Impact Factor in 2021. ISSN: 0887-6924. We aim to position HemaSphere as the information source for hematology with the news and views section termed … Furthermore, multiple drug-drug interactions need tobe takeninto account inthe RPL11 binds to the promoter regions of c-MYC target genes, thereby reducing c-MYC–dependent transcription ( 83 , 84 ). We can put registered members of Publons' reviewer community in touch with partnered journals they would like to review for. Bruce Feinberg, James Gilmore, Tom Gondesen, James H. Jackson, Mansoor Saleh, Impact of NCD guidelines on Medicare patients with chemotherapy-induced anemia receiving erythropoiesis-stimulating agents: results from a community oncology practice, Community Oncology, 10.1016/S1548-5315(11)70349-7, 6, 6, (257-261), (2009). Journal of Southern Hemisphere Earth Systems Science publishes broad areas of research with a distinct emphasis of the Southern Hemisphere. Parmi les indicateurs reconnus, mentionnons le Clarivate’s Journal Impact Factor (JIF) et l’indicateur CiteScore d’Elsevier, entre autres. Article suivant Meilleur Zhongli Build à Genshin Impact. Shape of Science. After the JAK1/2 inhibitor ruxolitinib, similar JAK2 inhibitors as fedratinib are entering clinical use. highlight recent chemical and preclinical advances in this space, leading to a large number of clinical candidates against a diverse range of targets in liver hepatocytes. Cancel Create. HemaSphere, Volume 5; doi:10.1097/hs9.0000000000000503. About Blood . Jordy C. G. Van Der Zwet, Willem Smits, Jessica G. C. A. M. Buijs-Gladdines, Rob Pieters, HemaSphere, Volume 5; doi:10.1097/hs9.0000000000000513. ISSN: 1554-8627. Perhaps even more important is the general impact that the journal will gain in the field. Does not allow reviews to be publicly displayed, Only allows reviewers to display the journal they reviewed for. As a newer journal, HemaSphere does not yet have an Impact Factor; however, HemaSphere is proud to be fully indexed in the PubMed Central (PMC) database. https://onlinelibrary.wiley.com/page/journal/13652141/homepage/forauthors.html This was the first demonstration that one of the rare autosomal recessive bleeding disorders could be treated with gene transfer. However, data about the association between blood cell count abnormalities, other than anemia, and health-related quality of life (HRQoL) are scarce. Compensatory signaling, which bypasses JAK2 inhibition, and other processes contribute to intrinsic resistance of MPN cells restricting efficacy of JAK2 inhibition overall. Here, we review the key developments in the gene therapy landscape for primary immune deficiency, from an experimental therapy where clinical efficacy was marred by adverse events, to a commercialized product with enhanced safety and efficacy. 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